The Use of Diffusion Weighted Imaging and Intravoxel Incoherent Motion to Assess Edema and Perfusion in Abdominal Organs during Endotoxemia

Diffusion weighted magnetic resonance imaging (DW-MRI) technique probing the microscopic movement of water molecules in tissue, allows for quantification diffusivity and contribution perfusion to total amount water. In last decades, its use organs other than brain has increased it successfully been applied abdominal organs; otherwise DWI assessment (by measuring fraction edema apparent diffusion coefficient—ADC) entire is not a clinical standard. The aim this paper assess whether DWI, specifically IVIM, can accurately (the contained tissue) (liver, spleen, intestine kidneys) an endotoxemic porcine model. Endotoxemia was induced 20 piglets they were divided into three groups: HM group (HighMAP, mean arterial pressure maintained >65 mmHg by noradrenaline infusion), LM (LowMAP, MAP between 50 60 mmHg) LTD thoracic duct ligated increase edema). addition, fourth healthy controls (four animals) underwent MRI. Edema also assessed wet–dry weight liver, spleen intestine; hemodynamics, lactate concentration SvO2. ADC found be higher compared with groups, accordance weight. kidneys correlated glomerular filtration rate. f hemodynamics liver. presented data show that there potential septic patients.